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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: DISC1 All Species: 13.33
Human Site: T207 Identified Species: 36.67
UniProt: Q9NRI5 Number Species: 8
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q9NRI5 NP_001012975.1 854 93611 T207 P G S H S A F T S S F S F I R
Chimpanzee Pan troglodytes XP_001151459 858 94064 T207 P D S H S A F T S S F S F I R
Rhesus Macaque Macaca mulatta NP_001107827 854 93125 A207 P G S H S A F A S S F S F I R
Dog Lupus familis XP_546088 886 96973 T241 A G S Q D A F T S S F S F I R
Cat Felis silvestris
Mouse Mus musculus Q811T9 852 92506 T209 P G F Q D T F T S S F S F I Q
Rat Rattus norvegicus Q810H6 846 92545 F203 L P G F Q D T F T S N F S F I
Wallaby Macropus eugenll
Platypus Ornith. anatinus
Chicken Gallus gallus
Frog Xenopus laevis Q9PTD7 1360 158447 G217 N G D Y P S L G Y R S A T S Q
Zebra Danio Brachydanio rerio NP_001135735 994 112198 S346 S G F L K P S S N L I N H L S
Tiger Blowfish Takifugu rubipres NP_001167643 596 65868 S26 I T E G G R V S G T A G S S A
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 97.1 94.3 69 N.A. 56.4 54.9 N.A. N.A. N.A. 20.2 25.2 22.7 N.A. N.A. N.A. N.A.
Protein Similarity: 100 97.6 96.8 75.7 N.A. 70.7 68.9 N.A. N.A. N.A. 35.4 41.8 36 N.A. N.A. N.A. N.A.
P-Site Identity: 100 93.3 93.3 80 N.A. 66.6 6.6 N.A. N.A. N.A. 6.6 6.6 0 N.A. N.A. N.A. N.A.
P-Site Similarity: 100 93.3 93.3 80 N.A. 73.3 13.3 N.A. N.A. N.A. 33.3 33.3 13.3 N.A. N.A. N.A. N.A.
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 12 0 0 0 0 45 0 12 0 0 12 12 0 0 12 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 12 12 0 23 12 0 0 0 0 0 0 0 0 0 % D
% Glu: 0 0 12 0 0 0 0 0 0 0 0 0 0 0 0 % E
% Phe: 0 0 23 12 0 0 56 12 0 0 56 12 56 12 0 % F
% Gly: 0 67 12 12 12 0 0 12 12 0 0 12 0 0 0 % G
% His: 0 0 0 34 0 0 0 0 0 0 0 0 12 0 0 % H
% Ile: 12 0 0 0 0 0 0 0 0 0 12 0 0 56 12 % I
% Lys: 0 0 0 0 12 0 0 0 0 0 0 0 0 0 0 % K
% Leu: 12 0 0 12 0 0 12 0 0 12 0 0 0 12 0 % L
% Met: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % M
% Asn: 12 0 0 0 0 0 0 0 12 0 12 12 0 0 0 % N
% Pro: 45 12 0 0 12 12 0 0 0 0 0 0 0 0 0 % P
% Gln: 0 0 0 23 12 0 0 0 0 0 0 0 0 0 23 % Q
% Arg: 0 0 0 0 0 12 0 0 0 12 0 0 0 0 45 % R
% Ser: 12 0 45 0 34 12 12 23 56 67 12 56 23 23 12 % S
% Thr: 0 12 0 0 0 12 12 45 12 12 0 0 12 0 0 % T
% Val: 0 0 0 0 0 0 12 0 0 0 0 0 0 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 12 0 0 0 0 12 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _